Single-molecule biophysics

Our lab combines molecular biology and biophysical techniques to understand mechanisms that underlie the cellular organization and motility. Single-molecule imaging and optical trapping allow us to directly observe molecular motions, time courses of reactions and heterogeneity in subpopulations of proteins.

 

One of our major goals is to understand how microtubular motors work individually and collectively to power intracellular transport and organismal motility. Another research focus is to determine how DNA-associated proteins alter the structure and spatial organization of DNA by using superresolution imaging techniques.

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