2022
Compartmentalization of telomeres through DNA-scaffolded phase separation
Amanda Jack, Yoonji Kim, Amy R Strom, Daniel SW Lee, Byron Williams, Jeffrey M Schaub, Elizabeth H Kellogg, Ilya J Finkelstein, Luke S Ferro, Ahmet Yildiz, Clifford P Brangwynne Developmental Cell
Luke S. Ferro*, Qianglin Fang*, Lisa Eshun-Wilson*, Jonathan Fernandes*, Amanda Jack, Daniel P. Farrell, Mert Golcuk, Teun Huijben, Katelyn Costa, Mert Gur, Frank DiMaio, Eva Nogales, Ahmet Yildiz Science
SARS-Cov-2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity
Mert Golcuk, Aysima Hacisuleyman, Sema Z Yilmaz, Elhan Taka, Ahmet Yildiz, Mert Gur J. Chem. Inf. Model.
The Omicron variant increases the interactions of SARS-CoV-2 spike glycoprotein with ACE2
Mert Golcuk, Ahmet Yildiz, M Gur J Mol. Graphics and Model.
2021
Critical interactions between the SARS-CoV-2 spike glycoprotein and the human ACE2 receptor
Elhan Taka, Selma Z Yilmaz, Mert Golcuk, Ceren Kilinc, Umut Aktas, Ahmet Yildiz, Mert Gur The Journal of Physical Chemistry B
John T Canty, Andrew Hensley, Ahmet Yildiz bioRxiv
Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike Glycoprotein
Mert Golcuk, Aysima Hacisuleyman, Burak Erman, Ahmet Yildiz, Mert Gur JCIM
The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics
Andrea Serra-Marques, Ronja Houtekamer, Dorine Hintzen, John T Canty, Ahmet Yildiz, Sophie Dumont Journal of Cell Biology
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
Amanda Jack, Luke S. Ferro, Michael J. Trnka, Eddie Wehri, Amrut Nadgir, Xammy Nguyenla, Douglas Fox, Katelyn Costa, Sarah Stanley, Julia Schaletzky, Ahmet Yildiz. PLoS Biology
2020
Lis1 activates dynein motility by modulating its pairing with dynactin
Mohamed M Elshenawy, Emre Kusakci, Sara Volz, Janina Baumbach, Simon L Bullock & Ahmet Yildiz. Nature Cell Biology
Dynein harnesses active fluctuations of microtubules for faster movement
Yasin Ezber, Vladislav Belyy, Sinan Can & Ahmet Yildiz. Nature Physics
2019
Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin
Mohamed M. Elshenawy *, John T. Canty *, Liya Oster, Luke S. Ferro, Zhou Zhou, Scott C. Blanchard & Ahmet Yildiz. Nature Chemical Biology
Kinesin-1 and dynein use distinct mechanisms to bypass obstacles
Luke S. Ferro, Sinan Can, Meghan A. Turner, Mohamed M. Elshenawy, Ahmet Yildiz. eLife
Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-CAS13A
Peiwu Qin, Myeongkee Park, Kendra J. Alfson, Manasi Tamhankar, Ricardo Carrion, Jean L. Patterson, Anthony Griffiths, Qian He, Ahmet Yildiz, Richard Mathies, Ke Du. ACS Sensors
Directionality of dynein is controlled by the angle and length of its stalk
Sinan Can *, Samuel Lacey *, Mert Gur, Andrew P. Carter and Ahmet Yildiz. Nature
2018
MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility
Guo Fu, Jigar N. Bandaria, Anne Valérie Le Gall, Xue Fan, Ahmet Yildiz, Tâm Mignot, David R. Zusman and Beiyan Nan. PNAS
Cryo-EM shows how dynactin recruits two dyneins for faster movement
Linas Urnavicius*, Clinton K. Lau*, Mohamed M. Elshenawy, Edgar Morales-Rios, Carina Motz, Ahmet Yildiz & Andrew P. Carter. Nature
2017
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz, Jennifer A. Doudna. Nature
Dynamics of the IFT machinery at the ciliary tip
Alexander Chien*, Sheng Min Shih*, Raqual Bower, Douglass Tritschler, Mary E Porter, Ahmet Yildiz. eLife
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
Yavuz S. Dagdas*, Janice S. Chen*, Samuel H. Sternberg, Jennifer A. Doudna, Ahmet Yildiz. Science Advances
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"Cas9 endonuclease and off-target activity", Ali Shilatifard. Science
Sara M. Wichner, Victor R. Mann, Alexander S. Powers, Maya A. Segal, Mustafa Mir, Jigar N. Bandaria, Mark A. DeWitt, Xavier Darzacq, Ahmet Yildiz, Bruce E. Cohen. ACS Nano
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
Peiwu Qin*, Mahmut Parlak*, Cem Kuscu, Jigar Bandaria, Ritambhara Singh, Mustafa Mir, Xavier Darzacq, Ahmet Yildiz and Mazhar Adli. Nature Communications
PhotoGate microscopy to track single molecules in crowded environments
Vladislav Belyy, Sheng-Min Shih, Jigar Bandaria, Yongjian Huang, Rosalie E. Lawrence, Roberto Zoncu, Ahmet Yildiz. Nature Communications
2016
The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition
Vladislav Belyy, Max A. Schlager, Helen Foster, Armando E. Reimer, Andrew P. Carter and Ahmet Yildiz. Nature Cell Biology
Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin
Jigar N. Bandaria, Peiwu Qin, Veysel Berk, Steven Chu and Ahmet Yildiz. Cell
2015
Beiyan Nan, Jigar N. Bandaria, Kathy Y. Guo, Xue Fan, Ahmet Yildiz and David R. Zusman. PNAS
The AAA3 Domain of Cytoplasmic Dynein Acts as a “Switch” to Facilitate Microtubule Release
Mark A. Dewitt, Caroline A. Cypranowska, Vladislav Belyy and Ahmet Yildiz. NSMB
Robert A. Wu, Yavuz S. Dagdas, S. Tunc Yilmaz, Ahmet Yildiz* and Kathleen Collins*. eLife
Kinesin's Front Head Is Gated by the Backward Orientation of Its Neck Linker
Yusra Satoglu-Dogan†, Sinan Can†, Frank B. Cleary, Vedud Purde and Ahmet Yildiz. Cell Reports
2014
Cytoplasmic Dynein Transports Cargos via Load-Sharing between the Heads
Vladislav Belyy, Nathan L. Hendel, Alexander Chien and Ahmet Yildiz. Nature Communications
Tension on the linker gates the ATP-dependent release of dynein from microtubules
Frank B. Cleary, Mark A. Dewitt, Thomas Bilyard, Zaw Min Htet, Vladislav Belyy, Danna D. Chan, Amy Y. Chang and Ahmet Yildiz. Nature Communications
Bidirectional helical motility of cytoplasmic dynein around microtubules
Sinan Can, Mark A. Dewitt and Ahmet Yildiz. eLife
G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding
Sujay Ray*, Jigar N. Bandaria*, Mohammad H. Qureshi, Ahmet Yildiz* and Hamza Balci*. PNAS
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“Single-Molecule Choreography between Telomere Proteins and G Quadruplexes”, Karl-Peter Hopfner. Structure
2013
Intraflagellar transport drives flagellar surface motility
Sheng-Min Shih, Benjamin D Engel, Fatih Kocabas, Thomas Bilyard, Arne Gennerich, Wallace F Marshall, and Ahmet Yildiz. eLife
Beiyan Nan*, Jigar N. Bandaria*, Amirpasha Moghtaderi, Im-Hong Sun, Ahmet Yildiz* and David R. Zusman*. PNAS
2012
Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains
Mark A. Dewitt, Amy Y. Chang, Peter A. Combs, and Ahmet Yildiz. Science
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“Molecular motors: A staggering giant”, Wilhelm J. Walter & Stefan Diez. Nature
Pre-2012
Erdal Toprak, Ahmet Yildiz, Melinda T. Hoffman, Steven S. Rosenfeld, and Paul R. Selvin. PNAS
Intramolecular strain governs kinesin stepping behavior along microtubules
Ahmet Yildiz, Michio Tomishige, Arne Gennerich, and Ron D. Vale. Cell (Featured article)
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“Kinesin Motors: No Strain, No Gain”, Jared C. Cochran and F. Jon Kull. Cell
Single-Molecule Analysis of Dynein Processivity and Stepping Behavior.
Sam L. Reck-Peterson, Ahmet Yildiz†, Andrew P. Carter†, Arne Gennerich, Nan Zhang, and Ron D. Vale. Cell
Step-size is Determined by Neck Length in Myosin V
Takeshi Sakamoto, Ahmet Yildiz, Paul R. Selvin, and James R. Sellers. Biochemistry
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“Walk like a Molecular Motor”, Paul R. Selvin, The Scientist
Myosin VI walks hand-over-hand with its lever arm undergoing fluctuations when attached to actin
Ahmet Yildiz, Hyokeun Park, Dan Safer, Zhaohui Yang, Li-Qiong Chen, Paul R. Selvin, and H.Lee Sweeney. J. Bio. Chem
Ahmet Yildiz, Michio Tomishige, Ron D. Vale, and Paul R. Selvin. Science
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“Cell's Motor Is a Mountain Climber, Not an Inchworm”, Ron Vale HHMI News
Myosin V walks hand-over-hand: Single fluorophore imaging with 1.5 nm localization
Ahmet Yildiz, Joseph N. Forkey, Sean A. McKinney, Taekjip Ha, Yale E. Goldman, and Paul R. Selvin. Science
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“Myosin Motors Walk the Walk”, C. Veigel & J. Molloy. Science
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Breakthroughs of the year: The Runners-up, News and Editorial Staff. Science
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Thomson ISR, one of the most cited papers in the research area of multidisciplinary (2003)
*equal contribution