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Compartmentalization of telomeres through DNA-scaffolded phase separation

Amanda Jack, Yoonji Kim, Amy R Strom, Daniel SW Lee, Byron Williams, Jeffrey M Schaub, Elizabeth H Kellogg, Ilya J Finkelstein, Luke S Ferro, Ahmet Yildiz, Clifford P Brangwynne Developmental Cell

Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7

Luke S. Ferro*, Qianglin Fang*, Lisa Eshun-Wilson*, Jonathan Fernandes*, Amanda Jack, Daniel P. Farrell, Mert Golcuk, Teun Huijben,  Katelyn Costa, Mert Gur, Frank DiMaio, Eva Nogales, Ahmet Yildiz Science

SARS-Cov-2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity

Mert Golcuk, Aysima Hacisuleyman, Sema Z Yilmaz, Elhan Taka, Ahmet Yildiz, Mert Gur J. Chem. Inf. Model.

The Omicron variant increases the interactions of SARS-CoV-2 spike glycoprotein with ACE2


Mert Golcuk, Ahmet Yildiz, M Gur J Mol. Graphics and Model.


Critical interactions between the SARS-CoV-2 spike glycoprotein and the human ACE2 receptor

Elhan Taka, Selma Z Yilmaz, Mert Golcuk, Ceren Kilinc, Umut Aktas, Ahmet Yildiz, Mert Gur The Journal of Physical Chemistry B

TRAK adaptors coordinate the recruitment and activation of dynein and kinesin to control mitochondrial transport


John T Canty, Andrew Hensley, Ahmet Yildiz bioRxiv

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike Glycoprotein


Mert Golcuk, Aysima Hacisuleyman, Burak Erman, Ahmet Yildiz, Mert Gur JCIM

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics


Andrea Serra-Marques, Ronja Houtekamer, Dorine Hintzen, John T Canty, Ahmet Yildiz, Sophie Dumont Journal of Cell Biology

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

Amanda Jack, Luke S. Ferro, Michael J. Trnka, Eddie Wehri, Amrut Nadgir, Xammy Nguyenla, Douglas Fox, Katelyn Costa, Sarah Stanley, Julia Schaletzky, Ahmet Yildiz. PLoS Biology


Lis1 activates dynein motility by modulating its pairing with dynactin


Mohamed M Elshenawy, Emre Kusakci, Sara Volz, Janina Baumbach, Simon L Bullock & Ahmet Yildiz. Nature Cell Biology


Dynein harnesses active fluctuations of microtubules for faster movement


Yasin EzberVladislav BelyySinan Can & Ahmet YildizNature Physics



Cargo adaptors regulate stepping and force generation of mammalian dynein–dynactin


Mohamed M. Elshenawy *, John T. Canty *, Liya Oster, Luke S. Ferro, Zhou Zhou, Scott C. Blanchard & Ahmet Yildiz. Nature Chemical Biology  

Kinesin-1 and dynein use distinct mechanisms to bypass obstacles

Luke S. Ferro, Sinan Can, Meghan A. Turner, Mohamed M. Elshenawy, Ahmet Yildiz. eLife

Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-CAS13A

Peiwu Qin, Myeongkee Park, Kendra J. Alfson, Manasi Tamhankar, Ricardo Carrion, Jean L. Patterson, Anthony Griffiths, Qian He, Ahmet Yildiz, Richard Mathies, Ke Du. ACS Sensors

Directionality of dynein is controlled by the angle and length of its stalk


Sinan Can *, Samuel Lacey *, Mert Gur, Andrew P. Carter and Ahmet Yildiz. Nature



MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility


Guo Fu, Jigar N. Bandaria, Anne Valérie Le Gall, Xue Fan, Ahmet Yildiz, Tâm Mignot, David R. Zusman and Beiyan Nan. PNAS

Cryo-EM shows how dynactin recruits two dyneins for faster movement

Linas Urnavicius*Clinton K. Lau*Mohamed M. ElshenawyEdgar Morales-RiosCarina MotzAhmet Yildiz & Andrew P. Carter.  Nature



Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.


Janice S. ChenYavuz S. DagdasBenjamin P. KleinstiverMoira M. WelchAlexander A. SousaLucas B. HarringtonSamuel H. SternbergJ. Keith JoungAhmet YildizJennifer A. Doudna. Nature

Dynamics of the IFT machinery at the ciliary tip

Alexander Chien*, Sheng Min Shih*, Raqual Bower, Douglass Tritschler, Mary E Porter, Ahmet Yildiz.  eLife


A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9


Yavuz S. Dagdas*, Janice S. Chen*, Samuel H. Sternberg, Jennifer A. Doudna, Ahmet Yildiz.  Science Advances


Covalent Protein Labeling and Improved Single-Molecule Optical Properties of Aqueous CdSe/CdS Quantum Dots


Sara M. Wichner, Victor R. Mann, Alexander S. Powers, Maya A. Segal, Mustafa Mir, Jigar N. Bandaria, Mark A. DeWitt, Xavier Darzacq, Ahmet Yildiz, Bruce E. Cohen.  ACS Nano


Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9


Peiwu Qin*, Mahmut Parlak*, Cem Kuscu, Jigar Bandaria, Ritambhara Singh, Mustafa Mir, Xavier Darzacq, Ahmet Yildiz and Mazhar Adli. Nature Communications


PhotoGate microscopy to track single molecules in crowded environments


Vladislav Belyy, Sheng-Min Shih, Jigar Bandaria, Yongjian Huang, Rosalie E. Lawrence, Roberto Zoncu, Ahmet Yildiz. Nature Communications



The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition


Vladislav Belyy, Max A. Schlager, Helen Foster, Armando E. Reimer, Andrew P. Carter and Ahmet Yildiz. Nature Cell Biology


Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin


Jigar N. Bandaria, Peiwu Qin, Veysel Berk, Steven Chu and Ahmet Yildiz. Cell


The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA


Beiyan Nan, Jigar N. Bandaria, Kathy Y. Guo, Xue Fan, Ahmet Yildiz and David R. Zusman. PNAS


The AAA3 Domain of Cytoplasmic Dynein Acts as a “Switch” to Facilitate Microtubule Release


Mark A. Dewitt, Caroline A. Cypranowska, Vladislav Belyy and Ahmet Yildiz. NSMB


Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes


Robert A. Wu, Yavuz S. Dagdas, S. Tunc Yilmaz, Ahmet Yildiz* and Kathleen Collins*. eLife


Kinesin's Front Head Is Gated by the Backward Orientation of Its Neck Linker


Yusra Satoglu-Dogan†, Sinan Can†, Frank B. Cleary, Vedud Purde and Ahmet Yildiz. Cell Reports



Cytoplasmic Dynein Transports Cargos via Load-Sharing between the Heads


Vladislav Belyy, Nathan L. Hendel, Alexander Chien and Ahmet Yildiz. Nature Communications


Tension on the linker gates the ATP-dependent release of dynein from microtubules


Frank B. Cleary, Mark A. Dewitt, Thomas Bilyard, Zaw Min Htet, Vladislav Belyy, Danna D. Chan, Amy Y. Chang and Ahmet Yildiz. Nature Communications


Bidirectional helical motility of cytoplasmic dynein around microtubules


Sinan Can, Mark A. Dewitt and Ahmet Yildiz. eLife


G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding


Sujay Ray*, Jigar N. Bandaria*, Mohammad H. Qureshi, Ahmet Yildiz* and Hamza Balci*. PNAS

  • “Single-Molecule Choreography between Telomere Proteins and G Quadruplexes”, Karl-Peter Hopfner. Structure



Intraflagellar transport drives flagellar surface motility


Sheng-Min Shih, Benjamin D Engel, Fatih Kocabas, Thomas Bilyard, Arne Gennerich, Wallace F Marshall, and Ahmet Yildiz. eLife


Flagella stator homologs function as motors for myxobacterial gliding motility by moving in helical trajectories


Beiyan Nan*, Jigar N. Bandaria*, Amirpasha Moghtaderi, Im-Hong Sun, Ahmet Yildiz* and David R. Zusman*. PNAS



Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains


Mark A. Dewitt, Amy Y. Chang, Peter A. Combs, and Ahmet Yildiz. Science

  • “Molecular motors: A staggering giant”, Wilhelm J. Walter & Stefan Diez. Nature



Why kinesin is so processive


Erdal Toprak, Ahmet Yildiz, Melinda T. Hoffman, Steven S. Rosenfeld, and Paul R. Selvin. PNAS


Intramolecular strain governs kinesin stepping behavior along microtubules


Ahmet Yildiz, Michio Tomishige, Arne Gennerich, and Ron D. Vale.  Cell (Featured article)

  • “Kinesin Motors: No Strain, No Gain”, Jared C. Cochran and F. Jon Kull. Cell


Single-Molecule Analysis of Dynein Processivity and Stepping Behavior.


Sam L. Reck-Peterson, Ahmet Yildiz†, Andrew P. Carter†, Arne Gennerich, Nan Zhang, and Ron D. Vale. Cell


Step-size is Determined by Neck Length in Myosin V


Takeshi Sakamoto, Ahmet Yildiz, Paul R. Selvin, and James R. Sellers. Biochemistry

  • “Walk like a Molecular Motor”, Paul R. Selvin, The Scientist


Myosin VI walks hand-over-hand with its lever arm undergoing fluctuations when attached to actin


Ahmet Yildiz, Hyokeun Park, Dan Safer, Zhaohui Yang, Li-Qiong Chen, Paul R. Selvin, and H.Lee Sweeney. J. Bio. Chem


Kinesin walks hand-over-hand


Ahmet Yildiz, Michio Tomishige, Ron D. Vale, and Paul R. Selvin. Science


Myosin V walks hand-over-hand: Single fluorophore imaging with 1.5 nm localization


Ahmet Yildiz, Joseph N. Forkey, Sean A. McKinney, Taekjip Ha, Yale E. Goldman, and Paul R. Selvin. Science

  • “Myosin Motors Walk the Walk”, C. Veigel & J. Molloy. Science

  • Breakthroughs of the year: The Runners-up, News and Editorial Staff. Science

  • Thomson ISR, one of the most cited papers in the research area of multidisciplinary (2003)

*equal contribution

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